Jane Lynch appeared in a single episode of The King of Queens as a fertility doctor who gives Doug (Kevin James) and his wife the news that they only have a few fertile days to try for a baby. Of course, this news comes right as their parents are coming for the weekend.
The Sandman plays one of Doug's old high school classmates who used to be a party animal but has since matured...or so Doug thinks. The two embark on a night of debauchery that goes wrong once Adam Sandler's Jeff "The Beast" Sussman escalates egging their old principal's car to breaking into a convenience store.
Kirstie Alley plays herself on the series as a difficult client for Carrie (Leah Remini) to deal with.
UnReal's Constance Zimmer plays Jenny, who works with Carrie at the office and is set up on a blind date with Spence (Patton Oswalt.)
The director, screenwriter and actor appeared in the "Trash Talker" episode during season 6, where he played Doug's old bully Sean McGee, who had tortured Doug back in the seventh grade by spreading a rumor around school that he licked trash.
Of course fans expected to see Ray Romano on The King of Queens, since the show is set in the same world of Romano's show Everybody Loves Raymond.
While Romano was only on four episodes of the sister show, his episodes were still memorable for the hilarious situations we saw him and Doug in, such as when Ray got Doug in trouble with his driver's test and lost him his license.
Just like Ray Romano, Patricia Heaton's Everybody Loves Raymond character made a few appearances on the sister show.
Saturday Night Live's Rachel Dratch hilariously played Denise Battaglia, the on-again, off-again girlfriend of Spence.
After Spence proclaims his love to her as she is at the altar with another man, she runs away with her former husband-to-be...but to another man at the wedding who also proclaims his love for her.
Before he played a terrifying meth lord on Breaking Bad, Bryan Cranston was Doug's annoying pool-owning neighbor who spends his time poking his head over the fence and trying to rope Doug into multi-level marketing schemes.
In the series' 100th episode, we see Arthur Spooner (the late Jerry Stiller) recollect his past, and in that flashback the actor's real-life son Ben Stiller plays the role of Arthur's father.